Abstract: To clarify the resilience development law of the selenium-rich agricultural industrial chain in Wenzhou City, a three-dimensional indicator system including resistance, recovery and upgrading was established on the basis of geological survey data of land quality and panel data from statistical yearbooks. The resilience of the selenium-rich agricultural industrial chain in Wenzhou was evaluated using the entropy weight method. The spatiotemporal evolution pattern and influencing factors of the selenium-rich agricultural industry in Wenzhou from 2011 to 2023 were analyzed by the coupling coordination degree model, Dagum Gini coefficient method and geodetector. The results indicate that the resilience of the selenium-rich agricultural industrial chain in Wenzhou exhibits a year-by-year increasing trend but remains at a low level in general. The development of the three subsystems is unbalanced, with recovery resilience acting as the weak link. The spatial disparity of resilience is prominent, and intra-regional disparity is the primary source. Scientific and technological input and agricultural development level are the core driving forces for the spatiotemporal differentiation of resilience. Fiscal support, urbanization level and mechanization degree generate significant interactive effects. The findings can provide empirical support for the high-quality development of selenium-rich agriculture.