Abstract: A total of 5 treatments were set up in the experiment, including water control (CK), 40% rice distemper EC (D₁₀₀), 40% reduction of EC from rice distemper by 20%+20% reduction of erythromycin WDG (D₈₀C), 40% reduction of EC from rice distemper by 20%+3% reduction of amino oligosaccharides AS (D₈₀A), and 140% reduction of rice distemper EC by 20%+2% Jinggangmycin · 800 million/g Bacillus cereus AS (D₈₀J). The field control effects of different chemical pesticides reduced and compounded with new biopesticides on major rice diseases in Hanzhong Basin were studied through continuous 2-year field experiments, as well as their impacts on rice yield, composition factors, and economic benefits. The results showed that the order of high and low efficacy of rice disease control was D₈₀C＞D₈₀A＞ D₈₀J＞D₁₀₀＞CK. The average efficacy of D₈₀C against rice blast disease ears and fingers was 89.56% and 92.71%, respectively. The average efficacy of D₈₀C against rice sheath blight ears and fingers was 75.88% and 83.04%, respectively. The average efficacy of D₈₀C against rice false smut ears and fingers was 83.45% and 85.35%, respectively. The grain yield of rice treated with D₈₀C and D₈₀A was significantly higher than that of other treatments, with an average increase of 15.80% and 13.61% compared to CK, respectively. The economic efficiency of rice is highest at D₈₀C, with an average increase of 17.76% and 7.51% in D₈₀C compared to CK and D₁₀₀ treatments, respectively. Correlation analysis shows that between rice grain yield is significantly positively correlated with the effectiveness of rice blast disease control, sheath blight control, and rice false smut control. In summary, the reduction of 40% rice distemper EC by 20% combined with 20% chloramphenicol WDG significantly improves the field control effect of rice diseases, increases rice yield and economic benefits, and is suitable for the application and promotion of disease reducing compound schemes on rice in Hanzhong.