Abstract: Based on the land use data of Urumqi from 2000 to 2020 for five periods, pressure-state-response (PSR) model was constructed to explore the temporal change law of ecological resilience of green space, and PLUS model was used to simulate the multi-scenario setting of the ecological resilience pattern of Urumqi in 2030. The results show that: (1) From 2000 to 2020, the ecological resilience of Urumqi showed a declining trend year by year, and showed a distribution pattern of“low in central China and high in four areas” in space. The level of ecological resilience has a certain correlation with urban expansion, and green space is the main contribution of ecological resilience. (2) Under the natural development scenario, the ecological resilience level of Urumqi is relatively balanced, but the overall resilience level needs to be improved. Under the scenario of urban development, human activities significantly disturb the ecosystem, leading to a significant decline in the level of ecological resilience, which needs to be paid great attention to. Under the ecological protection scenario, the ecological resilience level of Urumqi has been significantly improved by strengthening ecological protection measures, especially the emergence of extremely high resilience areas, which provides strong support for the sustainable development of the city. Therefore, strengthening urban planning and management, limiting the excessive expansion of construction land, protecting green space and natural landscape, and promoting ecological restoration are effective strategies to reduce the interference of urban ecological pressure and improve the level of ecological resilience.