Abstract: Based on the theory of “production-living-ecology” and the construction of the multi-functional evaluation index system of land use in Jiangsu Province, this paper uses the entropy method, comprehensive evaluation model and coupling coordination model to study the spatiotemporal distribution characteristics and driving factors of the coupling coordination degree of “production-living-ecological” functions of land use in 13 cities of Jiangsu Province from 2012 to 2021. The results show that: (1) The production function value of Jiangsu Province decreases from north to south and from two ends to the middle in the east-west direction. The high value area of life function is mainly distributed in the southern region. The high value area of ecological function is mainly distributed in the eastern region of Jiangsu Province. (2) The coupling coordination degree of land “production-living-ecological” functions in Jiangsu Province shows an overall upward trend in the time dimension, but there are obvious spatial differences, showing a structure of high in the eastern and southern regions and low in the western and northern regions. (3) The urban sewage treatment rate and the green coverage rate of built-up areas have a positive and significant impact on the coupling and coordination of land “production-living-ecological” functions in Jiangsu Province. The effects of labor input and public budget expenditure on the coupling and coordination of land “production-living-ecological” functions are not significant. In view of this, it is proposed to improve the quality of economic development to promote the coordination of “production-living-ecological” functions, formulate relevant policies to promote the coordination of “production-living-ecological” functions, improve sewage treatment rate and realize green development.