Abstract: The split zone test was adopted. The application of soil amendments was the main factor, and leaf retention treatment of Flue-cured Tobacco was the secondary factor. The local conventional fertilization without applying soil amendments was used as the control, and two treatments were set: conventional fertilization with soil amendments and nitrogen reduction of 20% with soil amendments. Using 22 leaves as a control and 19 leaves as one treatment, the effects of soil amendments and leaf retention on the growth and development of flue-cured tobacco NC297 were studied. The results showed that different combinations of soil amendments and leaf retention had significant or very significant effects on the agronomic traits, nutrient content, and economic traits of tobacco NC297. Among them, the nitrogen reduction of 20%+soil amendments and 19 leave retention treatments had the highest output value and proportion of medium to high quality tobacco, which was better than other treatments and helped to improve economic benefits. This result can provide a theoretical basis for the application of soil amendments and leaf retention treatment of flue-cured tobacco NC297 in Chuxiong Lyuhe production area.