Abstract: To achieve innovation-driven and high-quality development, it is urgent to innovate mechanisms and models, and crack the “last kilometer” problem of science and technology services. Based on an overall grasp of the changes in the supply and demand of agricultural science and technology services in the new era, by dissecting the structural contradictions of Jiangsu grape industry, this paper clarifies the connotation requirements and contradictions of the science and technology services of rural characteristic industries, and summarizes the science and technology service innovation mode formed in accordance with local conditions according to regional industrial characteristics, economic development level, science and technology resource distribution and other factors, and explores the endogenous mechanism and reconstruction conditions of local specialty science and technology services, so as to provide policy suggestions for optimizing the allocation of agricultural science and technology resources and improving the quality and efficiency of agricultural science and technology services.